I. EXECUTIVE SUMMARY The MRCT Center Post-trial Responsibilities: Continued Access to an Investigational Medicine Framework outlines a case-based, principled, stakeholder approach to evaluate and guide ethical responsibilities to provide continued access to an investigational medicine at the conclusion of a patient’s participation in a clinical trial. The Post-trial Responsibilities (PTR) Framework includes this Guidance Document as well as the accompanying Toolkit. A 41-member international multi-stakeholder Workgroup convened by the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard University (...) (MRCT Center) developed this Guidance and Toolkit. Project Motivation A number of international organizations have discussed the responsibilities stakeholders have to provide continued access to investigational medicines. The World Medical Association, for example, addressed post-trial access to medicines in Paragraph 34 of the Declaration of Helsinki (WMA, 2013): “In advance of a clinical trial, sponsors, researchers and host country governments should make provisions for post-trial access for all participants who still need an intervention identified as beneficial in the trial. This information must also be disclosed to participants during the informed consent process.” This paragraph and other international guidance documents converge on several consensus points: • Post-trial access (hereafter referred to as “continued access” in this Framework [for terminology clarification – see definitions]) is the responsibility of sponsors, researchers, and host country governments; • The plan for continued access should be determined before the trial begins, and before any individual gives their informed consent; • The protocol should delineate continued access plans; and • The plan should be transparent to potential participants and explained during the informed consent process. -/- However, there is no guidance on how to fulfill these responsibilities (i.e., linking specific responsibilities with specific stakeholders, conditions, and duration). To fill this gap, the MRCT Center convened a working group in September of 2014 to develop a framework to guide stakeholders with identified responsibilities. This resultant Framework sets forth applicable principles, approaches, recommendations and ethical rationales for PTR regarding continued access to investigational medicines for research participants. (shrink)

This paper explores the anatomical foundations of Aristotle's natural philosophy. Rather than simply looking at the body, he contrives specific procedures for revealing unmanifest phenomena. In some cases, these interventions seem extensive enough to qualify as experiments. At the work bench, one can observe the parts of animals in the manner Aristotle describes, even if his descriptions seem at odds with 20th century textbooks. Manipulating animals allows us to recover his teleological thought more fully. This consideration of Aristotle as a (...) sophisticated biologist helps our reading of his writings in other areas of philosophy. (shrink)

This article outlines in details specific experiments that Galen performed. It explores how his methodology for experimentation was a sophisticated response to the rationalist-empirist debate as it occurred in ancient medicine. -/- .

Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.

Functional diversity holds the promise of understanding ecosystems in ways unattainable by taxonomic diversity studies. Underlying this promise is the intuition that investigating the diversity of what organisms actually do—i.e. their functional traits—within ecosystems will generate more reliable insights into the ways these ecosystems behave, compared to considering only species diversity. But this promise also rests on several conceptual and methodological—i.e. epistemic—assumptions that cut across various theories and domains of ecology. These assumptions should be clearly addressed, notably for the sake (...) of an effective comparison and integration across domains, and for assessing whether or not to use functional diversity approaches for developing ecological management strategies. The objective of this contribution is to identify and critically analyze the most salient of these assumptions. To this aim, we provide an “epistemic roadmap” that pinpoints these assumptions along a set of historical, conceptual, empirical, theoretical, and normative dimensions. (shrink)

This article explores Galen's analysis of and response to the Rationalist and Empiricist medical sects. It argues that his interest in their debate concerning the epistemology of medicine and anatomy was key to his advancement of an experimental methodology.

A chronological presentation on man's religious beliefs focusing on Christianity and its early adversaries. From the Egyptian Pharaohs, Pagan Greek Gods, to various early Christian sects, this book establishes the similarities of faith.

In the remainder of this article, we will disarm an important motivation for epistemic contextualism and interest-relative invariantism. We will accomplish this by presenting a stringent test of whether there is a stakes effect on ordinary knowledge ascription. Having shown that, even on a stringent way of testing, stakes fail to impact ordinary knowledge ascription, we will conclude that we should take another look at classical invariantism. Here is how we will proceed. Section 1 lays out some limitations of previous (...) research on stakes. Section 2 presents our study and concludes that there is little evidence for a substantial stakes effect. Section 3 responds to objections. The conclusion clears the way for classical invariantism. (shrink)

The paper argues that an account of understanding should take the form of a Carnapian explication and acknowledge that understanding comes in degrees. An explication of objectual understanding is defended, which helps to make sense of the cognitive achievements and goals of science. The explication combines a necessary condition with three evaluative dimensions: an epistemic agent understands a subject matter by means of a theory only if the agent commits herself sufficiently to the theory of the subject matter, and to (...) the degree that the agent grasps the theory (i.e., is able to make use of it), the theory answers to the facts and the agent’s commitment to the theory is justified. The threshold for outright attributions of understanding is determined contextually. The explication has descriptive as well as normative facets and allows for the possibility of understanding by means of non-explanatory (e.g., purely classificatory) theories. (shrink)

In this article, we propose the Fair Priority Model for COVID-19 vaccine distribution, and emphasize three fundamental values we believe should be considered when distributing a COVID-19 vaccine among countries: Benefiting people and limiting harm, prioritizing the disadvantaged, and equal moral concern for all individuals. The Priority Model addresses these values by focusing on mitigating three types of harms caused by COVID-19: death and permanent organ damage, indirect health consequences, such as health care system strain and stress, as well as (...) economic destruction. It proposes proceeding in three phases: the first addresses premature death, the second long-term health issues and economic harms, and the third aims to contain viral transmission fully and restore pre-pandemic activity. -/- To those who may deem an ethical framework irrelevant because of the belief that many countries will pursue "vaccine nationalism," we argue such a framework still has broad relevance. Reasonable national partiality would permit countries to focus on vaccine distribution within their borders up until the rate of transmission is below 1, at which point there would not be sufficient vaccine-preventable harm to justify retaining a vaccine. When a government reaches the limit of national partiality, it should release vaccines for other countries. -/- We also argue against two other recent proposals. Distributing a vaccine proportional to a country's population mistakenly assumes that equality requires treating differently situated countries identically. Prioritizing countries according to the number of front-line health care workers, the proportion of the population over 65, and the number of people with comorbidities within each country may exacerbate disadvantage and end up giving the vaccine in large part to wealthy nations. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

We explore the question of whether machines can infer information about our psychological traits or mental states by observing samples of our behaviour gathered from our online activities. Ongoing technical advances across a range of research communities indicate that machines are now able to access this information, but the extent to which this is possible and the consequent implications have not been well explored. We begin by highlighting the urgency of asking this question, and then explore its conceptual underpinnings, in (...) order to help emphasise the relevant issues. To answer the question, we review a large number of empirical studies, in which samples of behaviour are used to automatically infer a range of psychological constructs, including affect and emotions, aptitudes and skills, attitudes and orientations (e.g. values and sexual orientation), personality, and disorders and conditions (e.g. depression and addiction). We also present a general perspective that can bring these disparate studies together and allow us to think clearly about their philosophical and ethical implications, such as issues related to consent, privacy, and the use of persuasive technologies for controlling human behaviour. (shrink)

Does the Ship of Theseus present a genuine puzzle about persistence due to conflicting intuitions based on “continuity of form” and “continuity of matter” pulling in opposite directions? Philosophers are divided. Some claim that it presents a genuine puzzle but disagree over whether there is a solution. Others claim that there is no puzzle at all since the case has an obvious solution. To assess these proposals, we conducted a cross-cultural study involving nearly 3,000 people across twenty-two countries, speaking eighteen (...) different languages. Our results speak against the proposal that there is no puzzle at all and against the proposal that there is a puzzle but one that has no solution. Our results suggest that there are two criteria—“continuity of form” and “continuity of matter”— that constitute our concept of persistence and these two criteria receive different weightings in settling matters concerning persistence. (shrink)

As quantum technologies (QT) advance, their potential impact on and relation with society has been developing into an important issue for exploration. In this paper, we investigate the topic of democratization in the context of QT, particularly quantum computing. The paper contains three main sections. First, we briefly introduce different theories of democracy (participatory, representative, and deliberative) and how the concept of democratization can be formulated with respect to whether democracy is taken as an intrinsic or instrumental value. Second, we (...) give an overview of how the concept of democratization is used in the QT field. Democratization is mainly adopted by companies working on quantum computing and used in a very narrow understanding of the concept. Third, we explore various narratives and counter-narratives concerning democratization in QT. Finally, we explore the general efforts of democratization in QT such as different forms of access, formation of grassroot communities and special interest groups, the emerging culture of manifesto writing, and how these can be located within the different theories of democracy. In conclusion, we argue that although the ongoing efforts in the democratization of QT are necessary steps towards the democratization of this set of emerging technologies, they should not be accepted as sufficient to argue that QT is a democratized field. We argue that more reflexivity and responsiveness regarding the narratives and actions adopted by the actors in the QT field and making the underlying assumptions of ongoing efforts on democratization of QT explicit, can result in a better technology for society. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

As biological and biomedical research increasingly reference the environmental context of the biological entities under study, the need for formalisation and standardisation of environment descriptors is growing. The Environment Ontology (ENVO) is a community-led, open project which seeks to provide an ontology for specifying a wide range of environments relevant to multiple life science disciplines and, through an open participation model, to accommodate the terminological requirements of all those needing to annotate data using ontology classes. This paper summarises ENVO’s motivation, (...) content, structure, adoption, and governance approach. (shrink)

According to recent social interactionist accounts in developmental psychology, a child's learning to talk about the past with others plays a key role in memory development. Most accounts of this kind are centered on the theoretical notion of autobiographical memory and assume that socio-communicative interaction with others is important, in particular, in explaining the emergence of memories that have a particular type of connection to the self. Most of these accounts also construe autobiographical memory as a species of episodic memory, (...) but its episodic character, as such, is not typically seen as falling within the remit of an explanation in social interactionist terms. I explore the idea that socio-communicative interaction centered on talk about the past might also have an important role to play, quite independently of considerations about the involvement of the self in memory, in accounting for the emergence of memories that are episodic in character, i.e., memories that involve the recollection of particular past events. In doing so, I also try to shed light on a distinctive role that talk about the past plays in socio-communicative interaction. (shrink)

This paper develops a normative framework for both conceptualizing and assessing various institutional possibilities for democratic modes of constitutional change, with special attention to the recent ferment of constitutional experimentation. The paper’s basic methodological orientation is interdisciplinary, combining research in comparative constitutionalism, political science and normative political philosophy. In particular, it employs a form of normative reconstruction: attempting to glean out of recent institutional innovations the deep political ideals such institutions embody or attempt to realize. Starting from the assumption that (...) contemporary constitutional democracies are attempting to realize the broader ideals of deliberative democratic constitution (ideals outlined briefly in the first section), the paper proposes an evaluative framework, comprised of six criteria, for assessing various mechanisms of constitutional change. It argues that democratic forms of constitutional change embody six distinct ideals—operationalizability, structural independence, democratic co-authorship, political equality, inclusive sensitivity, and reasons-responsiveness—and that these ideals can be used to gauge the normative worth of different mechanisms for carrying out such change. The framework is developed with reference to recent constitutional developments (e.g., in Venezuela, South Africa, Columbia, Bolivia, and Iceland) highlighting distinct criteria and showing how they appear to capture the general direction of institutional innovation. The paper conjectures that the set of six criteria yield the best normative reconstruction of the crucial ideals embodied in the constitutional change mechanisms of contemporary constitutional democracies, and so, ought to be used for purposes of evaluating institutional design proposals. (shrink)

We argue that while digital health technologies (e.g. artificial intelligence, smartphones, and virtual reality) present significant opportunities for improving the delivery of healthcare, key concepts that are used to evaluate and understand their impact can obscure significant ethical issues related to patient engagement and experience. Specifically, we focus on the concept of empowerment and ask whether it is adequate for addressing some significant ethical concerns that relate to digital health technologies for mental healthcare. We frame these concerns using five key (...) ethical principles for AI ethics (i.e. autonomy, beneficence, non-maleficence, justice, and explicability), which have their roots in the bioethical literature, in order to critically evaluate the role that digital health technologies will have in the future of digital healthcare. (shrink)

Propositional contingentism is the thesis that there might have been propositions which might have not have been something. Serious actualism is the thesis that it is impossible for a property to be exemplified without there being something which exemplifies it. Both are popular. Likewise, the dominant view in the metaphysics of modality is that metaphysical possibility and necessity can be understood – in some sense – in terms of possible worlds, i.e. total ways the world could have been. Here, I (...) argue that, given some minimal assumptions, the conjunction of propositional contingentism and serious actualism entails that worlds are modally fragile – every world is ontologically dependent on every proposition. I then show that such a consequence is inconsistent with the claim that propositions true at all possible worlds are necessary. (shrink)

The aim of the paper is to develop general criteria of argumentative validity and adequacy for probabilistic arguments on the basis of the epistemological approach to argumentation. In this approach, as in most other approaches to argumentation, proabilistic arguments have been neglected somewhat. Nonetheless, criteria for several special types of probabilistic arguments have been developed, in particular by Richard Feldman and Christoph Lumer. In the first part (sects. 2-5) the epistemological basis of probabilistic arguments is discussed. With regard to the (...) philosophical interpretation of probabilities a new subjectivist, epistemic interpretation is proposed, which identifies probabilities with tendencies of evidence (sect. 2). After drawing the conclusions of this interpretation with respect to the syntactic features of the probability concept, e.g. one variable referring to the data base (sect. 3), the justification of basic probabilities (priors) by judgements of relative frequency (sect. 4) and the justification of derivative probabilities by means of the probability calculus are explained (sect. 5). The core of the paper is the definition of '(argumentatively) valid derivative probabilistic arguments', which provides exact conditions for epistemically good probabilistic arguments, together with conditions for the adequate use of such arguments for the aim of rationally convincing an addressee (sect. 6). Finally, some measures for improving the applicability of probabilistic reasoning are proposed (sect. 7). (shrink)

Das spezifische Ziel von Argumentationen ist nicht einfach, den Adressaten etwas glauben zu machen - dies wäre bloße Rhetorik ﷓, sondern: den Adressaten beim Erkennen der Akzeptabilität (insbesondere der Wahrheit) der These anzuleiten und ihn so zu begründetem Glauben, zu Erkenntnis zu führen. Argumentationen leiten das Erkennen an, indem sie in ihren Argumenten hinreichende Akzeptabilitätsbedingungen der These als erfüllt beurteilen und so den Adressaten implizit auffordern, diese Bedingungen zu überprüfen. Argumentationen sind gültig, wenn sie prinzipiell das Erkennen anleiten können; d. (...) h. wenn die genannten Akzeptabilitätsbedingungen hinreichend sind, wenn sie tatsächlich erfüllt (die Argumente also wahr) sind und wenn es irgendjemanden gibt, der zwar die Akzeptabilität der Argumente, nicht aber die der These erkannt hat. Eine gültige Argumentation ist adäquat, um einen bestimmten Adressaten rational zu überzeugen, wenn dieser u. a. die Akzeptabilität der Argumente, nicht aber die der These erkannt hat. Die in gültigen Argumentationen als erfüllt beurteilten Akzeptabilitätsbedingungen sind Konkretisierungen allgemeiner Erkenntnisprinzipien für die spezifische These, z. B. des deduktiven Erkenntnisprinzips: 'Eine Proposition ist wahr, wenn sie von wahren Propositionen logisch impliziert wird.' oder des erkenntnisgenetischen Erkenntnisprinzips: 'Eine Proposition ist wahr, wenn sie korrekt verifiziert worden ist.' Eine Konkretisierung des deduktiven Prinzips für eine These p wäre z. B.: 'p ist wahr, 1. wenn q und r wahr sind und 2. wenn q und r zusammen p logisch implizieren.' Sind beide Bedingungen erfüllt, so könnte 'q; r; also p.' eine gültige deduktive Argumentation sein. Die verschiedenen Argumentationstypen unterscheiden sich danach, auf welchem Erkenntnisprinzip sie basieren. Das argumentativ angeleitete Erkennen der Akzeptabilität der These funktioniert so: Der Adressat benutzt das von ihm (zumindest implizit) gewußte allgemeine Erkenntnisprinzip als Checkliste, auf der er nach dem Vorbringen der Argumente abhakt, welche Akzeptabilitätsbedingung des Erkenntnisprinzips durch das Zutreffen des Arguments jeweils erfüllt wird. Auf der Basis dieser Funktionsbestimmung werden in der "Praktischen Argumentationstheorie" (erstmalig) präzise Gültigkeitskriterien für Argumentationen allgemein und für mehrere spezielle Argumentationstypen entwickelt, erkenntnistheoretisch begründet und auf komplexe Argumentationsbeispiele aus Philosophie, Wissenschaft, Technik und Kultur angewendet. Die Analyse der erkenntnistheoretischen Grundlagen - der zugrundeliegenden Erkenntnisprinzipien - vor allem der interpretierenden und praktischen Argumentationen ist zudem von erheblicher Bedeutung weit über die Argumentationstheorie hinaus: für die Interpretationstheorie, die Handlungstheorie und die praktische Philosophie. (shrink)

This paper aims to investigate the temporal content of perceptual experience. It argues that we must recognize the existence of temporal perceptions, i.e., perceptions the content of which cannot be spelled out simply by looking at what is the case at an isolated instant. Acts of apprehension can cover a succession of events. However, a subject who has such perceptions can fall short of having a concept of time. Similar arguments have been put forward to show that a subject who (...) has spatial perceptions can fall short of having a concept of space. In both cases, it is the fact that perception is from a point of view which stands in the way of it constituting an exercise of a concept of how things are objectively. However, the paper also shows that the way in which perception is perspectival takes a different form in each of the two cases. (shrink)

An epistemic agent A is a false epistemic authority for others iff they falsely believe A to be in a position to help them accomplish their epistemic ends. A major divide exists between what I call "epistemic quacks", who falsely believe themselves to be relevantly competent, and "epistemic charlatans", i.e., false authorities who believe or even know that they are incompetent. Both types of false authority do not cover what Lackey (2021) calls "predatory experts": experts who systematically misuse their social-epistemic (...) status as a cover for predatory behavior. Qua experts, predatory experts are competent and thus could (and maybe sometimes do) help their clients. But should we count them as genuine epistemic authorities? No, I argue, they are false epistemic authorities because, in addition to their practical and moral misconduct, such experts systematically deceive their clients, thereby thwarting the clients’ epistemic ends. (shrink)

This thesis is about Kant’s account of reason. In the Critique of Pure Reason, Kant introduces reason as an infinitely demanding faculty that seeks complete explanations for all observable phenomena. This account of reason is essential to Kant’s discussion in the Transcendental Dialectic and prompts the primary question of this thesis: how does Kant justify such an infinitely demanding faculty? How does he think we come to know that we have reason, so understood? Traditionally, Kant scholars have held that we (...) can grasp our mental faculties either through a priori awareness of their unique activities or through transcendental arguments. Both approaches, however, fail with reason, which presents unique metacritical challenges. We can never be aware of reason’s unique activities, which are infinite and so never complete, and reason cannot be established via transcendental argument because it is not necessary for the possibility of experience. So, how can we know that we have reason? This thesis breaks with tradition by arguing that reason gains self-knowledge in empirical psychology, the study of phenomena in inner sense. Reason, according to Kant, seeks to explain all phenomena, including those of inner sense. To explain inner phenomena, reason hypothesises mental faculties and their laws. Our ten- dency to ask why-questions, Kant argues, is best explained by hypothesising a faculty that demands complete explanations – i.e., reason. The thesis has five chapters. The first shows that, for Kant, mental facul- ties are (also) powers of inner sense. The second argues that the normative demands of these faculties are grounded in constitutive principles or laws. The third finds that the constitutive principle of reason requires us to sys- tematise powers of nature, which, as the fourth chapter explains, we do by hypothesising their respective laws. Finally, the fifth chapter suggests that reason hypothesises its own explanation-seeking law. (shrink)

The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, as these are a key technology to systematically integrate heterogeneous information about the aging process. Related topics were databases and data integration. Other talks tackled modeling issues and applications, the latter including talks focussed on marker development and cellular stress as well as on diseases, in particular on diseases of kidney (...) and skin. (shrink)

In this book some options concerning the greenhouse effect are assessed from a welfarist point of view: business as usual, stabilization of greenhouse gas emissions and reduction by 25% and by 60%. Up to today only economic analyses of such options are available, which monetize welfare losses. Because this is found to be wanting from a moral point of view, the present study welfarizes (among others) monetary losses on the basis of a hedonistic utilitarianism and other, justice incorporating, welfare ethics. (...) For these welfarist evaluations information about the social consequences of the four options are collected from the literature and eventually corrected; then the consequences for individual well-being are assessed based on psychological research about well-being dependent on the social situation of the individual; finally the aggregation formulas of the respective welfare ethics are applied to these data. Assessments by other types of ethics, e.g. Kantian ethic, are included. The strongest abatement option is found to be optimum with great unanimity. - In addition a cost-welfare analysis of greenhouse gas abatement is undertaken revealing efficient cost-welfare ratios for these measures and the most efficient ratio for the strongest option. - A final, more theoretical part discusses the moral obligations following from such evaluations. The notion of 'moral obligation' is explained in a way that, apart from moral goodness of the required act, reinforcement by formal or informal sanctions is another necessary condition for moral obligations. This leads to a conception of a historical morality according to which the demands of morality rise in the long run. Applying this conception to the greenhouse effect implies that presently we have the moral duty to raise the standards of greenhouse gas abatement as much as is politically feasible. (shrink)

My dissertation puts forward a critique of the phenomenal intentionality theory (PIT). According to standard accounts of PIT, all genuine intentionality is either identical to or partly grounded in phenomenal consciousness. I argue that it is a conceptually significant mistake to construe conscious experiences in terms of token mental states that instantiate phenomenal properties. This mistake is predicated on ignoring an important difference in the temporal character—what I call the “temporal shape”—between states and properties as opposed to conscious experiences. States (...) and properties lack a temporal shape, but conscious experience has a temporal shape. Thus, in order to adequately capture our phenomenology of temporality we need a mental ontology that adequately reflects this distinction. A second aim of this dissertation is to defend a mereological account of phenomenal intentionality, which says that phenomenality and intentionality are related by being proper parts of a first-personal, subjective, mental event. On this approach, the conditions of satisfaction for a subject’s first-personal, subjective, mental event just are the conditions of satisfaction for phenomenal intentionality. I explore the theoretical grounds for a mereological account of phenomenal intentionality and conclude that it does a better job of explaining difficult cases like the problem of unconscious thought (e.g., your belief that “grass is green”). Thus, we have prima facie support for a mereological account of phenomenal intentionality exactly where competing accounts fail. (shrink)

The article develops and justifies, on the basis of the epistemological argumentation theory, two central pieces of the theory of evaluative argumentation interpretation: 1. criteria for recognizing argument types and 2. rules for adding reasons to create ideal arguments. Ad 1: The criteria for identifying argument types are a selection of essential elements from the definitions of the respective argument types. Ad 2: After presenting the general principles for adding reasons (benevolence, authenticity, immanence, optimization), heuristics are proposed for finding missing (...) reasons, for deductive arguments, e.g., semantic tableaux are suggested. (shrink)

Although existing work draws attention to a range of obstacles in realizing fair AI, the field lacks an account that emphasizes how these worries hang together in a systematic way. Furthermore, a review of the fair AI and philosophical literature demonstrates the unsuitability of ‘treat like cases alike’ and other intuitive notions as conceptions of fairness. That review then generates three desiderata for a replacement conception of fairness valuable to AI research: (1) It must provide a meta-theory for understanding tradeoffs, (...) entailing that it must be flexible enough to capture diverse species of objection to decisions. (2) It must not appeal to an impartial perspective (neutral data, objective data, or final arbiter.) (3) It must foreground the way in which judgments of fairness are sensitive to context, i.e., to historical and institutional states of affairs. We argue that a conception of fairness as appropriate concession in the historical iteration of institutional decisions meets these three desiderata. On the basis of this definition, we organize the insights of commentators into a process-structure map of the ethical territory that we hope will bring clarity to computer scientists and ethicists analyzing Fair AI while clearing some ground for further technical and philosophical work. (shrink)

According to traditional theism, God alone exists a se, independent of all other things, and all other things exist ab alio, i.e., God both creates them and sustains them in existence. On the face of it, divine "aseity" is inconsistent with classical Platonism, i.e., the view that there are objectively existing, abstract objects. For according to the classical Platonist, at least some abstract entities are wholly uncreated, necessary beings and, hence, as such, they also exist a se. The thesis of (...) theistic activism purports to reconcile divine aseity with a robust Platonism. Specifically, the activist holds that God creates the abstract objects no less than the contingent concrete objects of the physical universe and hence that, like all created things, they exist ab alio after all, their necessity notwithstanding. But many philosophers believe a severe roadblock for activism remains — a problem known as the bootstrapping objection. Despite widespread faith in the deliverances of this argument, in this paper I show that the bootstrapping objection is open to significant objections on several fronts. (shrink)

Many researchers consider cancer to have molecular causes, namely mutated genes that result in abnormal cell proliferation (e.g. Weinberg 1998). For others, the causes of cancer are to be found not at the molecular level but at the tissue level where carcinogenesis consists of disrupted tissue organization with downward causation effects on cells and cellular components (e.g. Sonnenschein and Soto 2008). In this contribution, I ponder how to make sense of such downward causation claims. Adopting a manipulationist account of causation (...) (Woodward 2003), I propose a formal definition of downward causation and discuss further requirements (in light of Baumgartner 2009). I then show that such an account cannot be mobilized in support of non-reductive physicalism (contrary to Raatikainen 2010). However, I also argue that such downward causation claims might point at particularly interesting dynamic properties of causal relationships that might prove salient in characterizing causal relationships (following Woodward 2010). (shrink)

A questão “por quê ser moral”, que foi formulada expressamente no contexto do debate filosófico acadêmico por Francis Herbert Bradley, divide os leitores quando buscam sua resposta em Kant. Uns acham, como Gerold Prauss, que Kant negue a possibilidade de tal resposta e diga que a moral precisa ser aceita como um fato simplesmente dado, o “fato da razão”. Contudo, como tal imediatismo ou “decisionismo transcendental” parece insatisfatório, um outro grupo defende a assim chamada “interpretação do agente racional”, onde este (...) último apresenta o valor supremo, absoluto, que fundamenta a moral e, com isso, apresenta a razão em virtude da qual devemos agir moralmente. Mas tal valor absoluto ou já é moral, mas então a resposta dada à questão “por quê ser moral” entra num círculo vicioso. Ou tal valor faz a moral depender de algo fora da moral o que, conforme Kant, destruiria toda moral. A solução do problema é a seguinte: Kant não deriva a moral de um pressuposto extramoral nem pressupõe a própria moral como simplesmente dada, mas explica o originar da moral. Ela origina da razão prática pela volta dessa razão sobre si mesma que constitui sua autonomia. Por este seu originar, a moral não é uma mera derivação de algo pressuposto, mas algo radicalmente novo, original, autónomo. Pelo outro lado, existe, sim, uma fundamentação da moral, i.e., um processo compreensível de sua constituição. Com isso, Kant evita o imediatismo: a moral não precisa ser simplesmente aceita como um fato puro, mas pode ser compreendida pela razão. (shrink)

This paper argues that we should reject G. E. Moore’s anti-skeptical argument as it is presented in “Proof of an External World.” However, the reason I offer is different from traditional objections. A proper understanding of Moore’s “proof” requires paying attention to an important distinction between two forms of skepticism. I call these Ontological Skepticism and Epistemic Skepticism. The former is skepticism about the ontological status of fundamental reality, while the latter is skepticism about our empirical knowledge. Philosophers often assume (...) that Moore’s response to “external world skepticism” deals exclusively with the former, not the latter. But this is a mistake. I shall argue that Moore’s anti-skeptical argument targets an ontological form of skepticism. Thus, the conclusion is an ontological claim about fundamental reality, while the premises are epistemic claims. If this is correct, then the conclusion outstrips the scope of its premises and proves too much. (shrink)

Jeff McMahan has long shown himself to be a vigorous and incisive critic of speciesism, and in his essay “Our Fellow Creatures” he has been particularly critical of speciesist arguments that draw inspiration from Wittgenstein. In this essay I consider his arguments against speciesism generally and the species-norm account of deprivation in particular. I argue that McMahan's ethical framework is more nuanced and more open to the incorporation of speciesist intuitions regarding deprivation than he himself suggests. Specifically, I argue that, (...) given his willingness to include a comparative dimension in his “Intrinsic Potential Account” he ought to recognize species as a legitimate comparison class. I also argue that a sensible speciesism can be pluralist and flexible enough to accommodate many of McMahan's arguments in defense of “moral individualist” intuitions. In this way, I hope to make the case for at least a partial reconciliation between McMahan and the “Wittgensteinian speciesists”, e.g. Cora Diamond, Stephen Mulhall, and Raimond Gaita. (shrink)

This article develops an argument in defense of the claim that Aquinas holds that there are some kinds of activities which can be performed only by persons. In particular, it is argued that Aquinas holds that only persons can engage in the activities proper to a rational nature, e.g., the activities of intellect and will. Next, the article turns to discuss two implications of this thesis concerning Aquinas’s concept of a person. First, the thesis can be used to resolve a (...) prominent scholarly debate concerning Aquinas’s views on the possibility of human persons surviving their bodily deaths. Second, it also points to a problem with a leading interpretation of Aquinas’ account of the Christian doctrine of the Incarnation. Finally, the article concludes by discussing how a correct interpretation of Aquinas’s views on these matters is related to a broader scholarly debate concerning the history of the Western concept of a person. (shrink)

Over the last eighty years, studies in play have carved out a small, but increasingly significant, niche within the social sciences and a rich repository has been built which underscores the importance of play to social, cultural, and psychological development. The general point running through these works is a philosophical recognition that play should not be separated from the trappings of everyday life, but instead should be seen as one of the more primordial aspects of human existence. Gadamer is one (...) philosopher frequently associated with interest in play. In his magnum opus, Truth and Method (1960), Gadamer insisted the significance of play to human understanding is not merely recreational, but rather it discloses the full context of any given situation by promoting a freedom of possibilities within the horizon of one’s own life-world (i.e. the world directly and immediately experienced). As such, his philosophical analysis of play was essential to his overall project of philosophical hermeneutics as it can explain how meaning is not derived from something essential within a text, but rather considered from a full range of possibilities. There are good reasons to expand on that understanding of play within philosophical studies and we suggest one way to do so is to compare Gadamer’s treatment of play with similar ideas from thinkers often associated with other philosophical schools. Although there are other candidates (e.g. Wittgenstein’s language games) for such an analysis, we limit our comparison here to the notion of transaction, as treated by the American pragmatist John Dewey in his volume Knowing and the Known (co-authored with Arthur Bentley in 1949). Because Dewey tied his conception of transaction to an overarching philosophy of inquiry, we believe comparing it to Gadamer’s use of play can highlight the deep philosophical import of this concept to the understanding of philosophical inquiry. (shrink)

This paper takes up David Kaplan's suggestion that the phenomenon of cognitive dynamics can be approached via a study of what it takes for someone to change her mind. It is argued that in order for a subject to be able to change her mind about something, there must be occasions on which the following is the case: (1) First, the subject believed of an 'x' that it was f, now she believes of 'x' that it is not-f. (2) She (...) stopped believing of 'x' that it was f before she started believing of 'x' that it was not-f. (3) She knows that (1) and (2). The first part of the investigation shows why (1) - (3) are necessary within an account of what it is for someone to change her mind. The second part focuses on condition (3) and argues that it entails that the sameness or difference of thought content over time must sometimes be an epistemic given, i.e., that the subject can know that a thought she entertains now is the same as a thought she entertained earlier. (shrink)

In this paper, I consider the role of perspective in Hegel’s metaphysics, and in particular the role that multiple perspectives play within the ultimate structure in Hegel’s metaphysics, which Hegel calls ‘the idea [die Idee].’ My (somewhat anachronistic) way into this topic will be to inquire about Hegel’s stance on what Adrian Moore has called ‘absolute representations.’ I argue for the claim that perspective is maintained, even in the absolute idea, which generates the task of understanding the nature of that (...) perspective and its compatibility with absoluteness. I attempt to accomplish this task by asking what a logical perspective could be, and how it might be related to visual perspective. Then I inquire into the relation that perspectives have to each other, i.e., to the system of perspectives. I construe those relations in reciprocal and dynamic terms, so that absoluteness takes the form of a structured round of perspectives rather than a relation to reality “once and for all”. (shrink)

Our reception of Hegel’s theory of action faces a fundamental difficulty: on the one hand, that theory is quite clearly embedded in a social theory of modern life, but on the other hand most of the features of the society that gave that embedding its specific content have become almost inscrutably strange to us (e.g., the estates and the monarchy). Thus we find ourselves in the awkward position of stressing the theory’s sociality even as we scramble backwards to distance ourselves (...) from the particular social institutions that gave conceptualized form to such sociality in Hegel’s own opinion. My attempt in this article is to make our position less awkward by giving us at least one social-ontological leg to stand on. Specifically, I want to defend a principled and conceptual pluralism as forming the heart of Hegel’s theory of action. If this view can be made out, then we will have a social-ontological structure that might be filled out in different ways in Hegel’s time and our own while simultaneously giving real teeth to the notion that Hegel’s theory of action is essentially social. (shrink)

Spinoza rarely refers to art. However, there are extensive resources for a Spinozist aesthetics in his discussion of health in the Ethics and of social affects in his political works. There have been recently been a few essays linking Spinoza and art, but this essay additionally fuses Spinoza’s politics to an affective aesthetics. Spinoza’s statements that art makes us healthier (Ethics 4p54Sch; Emendation section 17) form the foundation of an aesthetics. In Spinoza’s definition, “health” is caused by external objects that (...) maintain our power to act in a variety of ways. Humans need such objects because our complex bodies constantly lose or consume many parts necessary to our overall functioning. Notably, Spinoza defines humans’ bodies through this complexity (2p13Sch), so health as maintenance of complexity is a distinctly human endeavor. Further, while art is not the only healthy activity, I argue that art is a particularly potent cure, which explains Spinoza’s otherwise opaque comment that music can cure melancholy (by which he meant a near-total inability to act, akin to death). Rather than only causing frivolous pleasures, art may be as essential to human flourishing as are other human beings in general; other people are “most useful” because of the variety of actions they make possible (4p35Cor & Sch1). Art’s production of a dizzying variety of affects is likewise most useful for health. -/- Having established how art in general affects the individual, I then explain the role of artists in shaping social groups. Artists use vivid and highly charged affective techniques, as do political sovereigns and religious prophets (TTP chapters 1-2 & 15-16). However, sovereigns and prophets are concerned exclusively with “morality,” defined by Spinoza as the use of affects (primarily based on fear and hope) to produce “obedience” in the generic multitude or people at large. An artist, however, rarely causes affects in the whole nation, affecting instead only a smaller niche or “sub-genre” of people. The affects produced in this group are also not identical to those used by sovereigns, since artists do not primarily deploy sad affects of hope and fear but instead use a wide variety of joyful affects. Further, in Spinoza’s analysis of ceremonies (TTP chapter 5), we see how small groups exposed to repeated ceremonies or social practices eventually develop new strengths which they lacked before. Repeated exposure to shared aesthetic “ceremonies” (e.g., live music performances) of the same sub-genre will over time create the capacity of new powers in the sub-genre of people, which distinguishes them from the masses. Spinoza says sovereigns forge a “second nature” for the generic people through affects; we can then affirm that smaller groups exposed to a distinct sub-genre of art can acquire a new “third nature” which will contain unique powers extending beyond healthy maintenance of their existing bodies. That is, art in general is necessary to flourish and remain whole (maintaining health), but it can also occasionally expand what one is to unforeseen heights (through specific artistic sub-genres). (shrink)

One of the reasons why there is no Hegelian school in contemporary ethics in the way that there are Kantian, Humean and Aristotelian schools is because Hegelians have been unable to clearly articulate the Hegelian alternative to those schools’ moral psychologies, i.e., to present a Hegelian model of the motivation to, perception of, and responsibility for moral action. Here it is argued that in its most basic terms Hegel's model can be understood as follows: the agent acts in a responsible (...) and thus paradigmatic sense when she identifies as reasons those motivations which are grounded in his or her talents and support actions that are likely to develop those talents in ways suggested by his or her interests. (shrink)

Desire', 'preference', 'utility', '(utility-aggregating) moral desirability' are terms that build on each other in this order. The article follows this definitional structure and presents these terms and their justifications. The aim is to present welfare-ethical criteria of the common good that define 'moral desirability' as an aggregation, e.g. addition, of individual utility: utilitarianism, utility egalitarianism, leximin, prioritarianism.

Nell'alto medioevo vi erano tre possibilità per il filosofo che volesse difendere l'esistenza degli universali: in primo luogo ante rem, seguendo la linea platonico-agostiniana degli universali trascendenti e questa è la via teologica; in secondo luogo la via post rem, cioè la via del concettualismo, conosciuta oggi come astrattismo, per cui gli universali sono il prodotto dell'astrazione della mente e questa è una via logica; la terza via è quella in re e difende gli universali immanenti che esistono negli universali (...) ed è una risposta ontologica. La seconda via fu difesa da Boezio nel secondo commento a Porfirio. La prima teoria è stata generalmente accettata da tutti i filosofi dell'alto medioevo eccetto Abelardo, mentre la terza via, quella degli universali immanenti, che ha come fonti antiche l'Isagoge di Porfirio e le Categoriae di Aristotele, fu difesa principalmente da quattro autori: Giovanni Scoto Eriugena, Anselmo d'Aosta, Odone di Cambrai e Guglielmo di Champeaux. L'A. prende in esame e confronta le soluzioni di Anselmo di Canterbury e Odone di Cambrai. (shrink)

English: Effective altruism has focused on moral efficiency, i.e. the ratio of the resources used (money, time ...) to the moral benefit achieved, in addition to the extent of our moral commitment, and has called for the maximum efficiency of moral commitment. This raises two questions, among others, which are the subject of this paper: 1. How does one calculate moral efficiency? 2. Is maximum moral efficiency the right moral decision-making criterion? In the article, efficiency calculations of donations for two (...) charitable projects are presented in detail (question 1): distribution of mosquito nets in malaria areas in sub-Saharan Africa and maintenance of a children's village in Guatemala. The result is that the children's village project is clearly less efficient. Should it therefore be abandoned, although it seems to be a very useful project (question 2)? (shrink)

American History X (hereafter AHX) has been accused by numerous critics of a morally dangerous cinematic seduction: using stylish cinematography, editing, and sound, the film manipulates the viewer through glamorizing an immoral and hate-filled neo-nazi protagonist. In addition, there’s the disturbing fact that the film seems to accomplish this manipulation through methods commonly grouped under the category of “fascist aesthetics.” More specifically, AHX promotes its neo-nazi hero through the use of several filmic techniques made famous by Nazi propagandist Leni Riefenstahl. (...) Now most critics admit that, in the end, the film claims to denounce racism and attempts to show us the conversion of the protagonist to the path of righteousness, but they complain that nonetheless the film (perhaps unintentionally) ends up implicitly promoting the immoral worldview it rather superficially professes to reject in its final act. This charge of hypocrisy is connected to another worry: the moral conversion in the film is said to fall flat because the intellectual resources on display to support the character’s racism are not counterbalanced by equally explicit (but superior) arguments for the anti-racist position ultimately embraced by the character. In other words, just as the devil is said to get all the good lines in Milton’s Paradise Lost, in AHX the racists get all the arguments. This has been taken to be a morally problematic flaw of the film. Critics lament that Derek’s conversion seems to result not from relevant logical inferences and valid rational argumentation but from overly simplistic and arguably egoistic insights (e.g., “has anything you've done made your life better?”) combined, perhaps, with a hackneyed cliché (in prison, one of his best friends is a black person!) In this paper I’ll attempt to rebut these charges and defend the film as a powerful, and powerfully moral, work of art. I’ll be suggesting that the seductive techniques employed allow for many viewers a degree of sympathy towards the protagonist that is crucial, both for making that character’s more horrific actions especially unsettling, and also for making his eventual conversion plausible and ultimately compelling. I’ll also argue that the manner in which his conversion is presented is in fact subtler than many critics have allowed: Derek’s transformation is not artificial or implausible but is depicted as resulting from a cumulative series of emotionally powerful life events and personal engagements. It is certainly true that it is not represented in the way some would seemingly have preferred, i.e. as straightforwardly resulting from a process of gradual intellectual improvement in Derek’s reasoning on questions of race and politics. However, I’ll argue that the decidedly emotional basis of his moral evolution is both refreshingly realistic and no hindrance to accepting his conversion as rational. Finally, properly understanding the legitimacy of the emotional foundations of much moral thought will also allow us to appreciate the ways in which our initial worries about this film’s (not insignificant) ability to persuade viewers through the engagement of emotions need not, in itself, be seen as a barrier to endorsing the film as a morally praiseworthy work. (shrink)

José Ángel Gascón’s essay "Where are dissent and reasons in epistemic justification?" is an exposition of a version of a social functionalist epistemology. I agree with Gascón's emphasis on reasons and on taking into account dissent as important parts of epistemology. But I think that these concerns do not require a social functionalist epistemology, but that, on the contrary, Gascón's social functionalist epistemology throws the baby out with the bathwater. It does so by excluding also a traditional, at its core (...) individualistic epistemology, which defines central concepts like 'justified', 'knowledge' still in individualistic terms as the result of a mental cognizing process but is open to social extensions, e.g. concerning cooperation in the acquisition of knowledge or the transfer of knowledge via argumentation. Such a socially open epistemology with an individualistic core – or "open individualistic epistemology" for short – is also the basis of the epistemological argumentation theory. In the following I want to explain and defend this open individualistic epistemology together with the epistemological argumentation theory (sect. 2) and explain on this basis some problems of Gascón’s theory (sect. 3). (shrink)

In this paper, first the term 'prioritarianism' is defined, with some mathematical precision, on the basis of intuitive conceptions of prioritarianism, especially the idea that "benefiting people matters more the worse off these people are". (The prioritarian weighting function is monotonously ascending and concave, while its first derivation is smoothly descending and convex but positive throughout.) Furthermore, (moderate welfare) egalitarianism is characterized. In particular a new symmetry condition is defended, i.e. that egalitarianism evaluates upper and lower deviations from the social (...) middle symmetrically and equally negatively (as do e.g. variance and Gini). Finally, it is shown that this feature distinguishes egalitarianism also extensionally from prioritarianism. (shrink)

“Dalla filosofia dell’azione alla filosofia della mente” è stato il percorso di alcuni filosofi di nazionalità varia degli anni 1980 – come Paul Churchland negli Stati Uniti o Ansgar Beckermann in Germania – che prima si sono interessati agli aspetti più teorici nella filosofia dell’azione, come il modo di funzionamento delle azioni e la loro spiegazione scientifica, e che poi, con l’arrivo e la diffusione dei personal computers e delle scienze cognitive, hanno ampliato e approfondito questo interesse di ricerca e (...) si sono dedicati alla filosofia della mente più in generale e in particolare alla spiegazione scientifica e filosofica del mentale. Sandro Nannini faceva parte di questo movimento ed è stato uno tra gli inizialmente pochi filosofi italiani che si sono occupati di questi argomenti; successivamente ne è diventato uno dei maggiori specialisti in Italia, proponendo una sua particolare versione di naturalizzazione del mentale. Subordinata agli interessi teorici è stata la sua iniziativa accademica di fondare e promuovere il primo dottorato italiano di ricerca in Scienze Cognitive. Il presente volume tratta dell’opera di Sandro Nannini in contributi che sono riflessioni più o meno specifiche sulle differenti tappe del suo percorso, affrontando temi come l’analisi dell'azione, il libero arbitrio, la discussione di Nannini di vari classici della filosofia, la tendenza del naturalismo a dissolvere la filosofia in un enciclopedismo empirico e la sfida dei qualia e della fenomenologia all’approccio naturalistico alla mente. Il volume contiene inoltre un saggio dello stesso Sandro Nannini, nel quale espone l’ultimo sviluppo della sua filosofia della mente nonché le risposte agli interventi degli altri autori: Mario De Caro, Sara Dellantonio, Rosaria Egidi, Roberta Lanfredini, Christoph Lumer, Paolo Parrini, Pietro Perconti, Claudio Pizzi, Emanuela Scribano e Giuseppe Varnier. (shrink)

The notions of information, representation and enaction entertain historical and complex relations with cognition. Historical relations because representational structures belong to the central hypothesis of cognitive sciences. Complex relations because cognitive sciences apply the notion of representation to animals, humans and robots, and also because the enactive approach tends to disregard the GOFAI type of representations. In this wide horizon of relations, we propose to look at a systemic approach that could bring up a common denominator for information and representations (...) in the build up of cognition, and also keep a link with the enactive approach. Our purpose is to show that systems submitted to constraints can generate meaningful information to maintain their natures, and consequently build up meaningful representations that have some compatibility with the enactive approach. Such a systemic approach to the notion of meaningful information could then make available a link between enaction and meaningful representations. The first part of the presentation is about reminding that cognition does not exist per se, but is related to the system that builds it. We look at cognition as constituted by dynamic meaningful representations built up by systems that have constraints to satisfy in their environments. Cognition is considered here at the level of the system that builds it and uses it in order to maintain its nature in its environment. Such a systemic approach fits with evolution. Organisms build representations to cope with survival constraints (frogs build representations of moving black dots in order to satisfy food constraints). Humans build representations and cognition to satisfy constraints that are conscious and unconscious. Artificial systems can use representations and cognition to run activities related to constraints implemented by the designers or coming from the environment (a goal to reach being considered as a constraint to satisfy). In the second part of the presentation we define what are a meaningful information and a representation for a system submitted to a constraint in its environment, and we link these to the enactive approach. We define a meaningful information (a meaning) as an information generated by a system submitted to a constraint when it receives an external information that has a connection with the constraint. The meaning is precisely that connection. The meaning belongs to the interactions that link the system to its environment. The function of the meaning is to participate to the determination of an action that will be implemented in order to satisfy the constraint. (Menant, 2003). The satisfaction of the constraint goes with maintaining the nature of the system in its environment. A Meaning Generator System (MGS) is defined correspondingly. It is a building block for higher level systems. We present some characteristics of the MGS (groundings of a meaning, domain of efficiency and transfer of meanings, networking of meanings, evolutionary usage). The MGS approach is close to a simplified version of the Peircean triadic theory of signs (Menant, 2003, 2005 ). We define the representation of an item for a system as being the dynamic set of meaningful information corresponding to the item for the system in its environments (an elementary representation being made of a single meaningful information). These representations link the system to its environment by their meaningful components related to the nature of the system. These representations are different from the GOFAI ones. The possibilities for linking these notions of meaning and representation with the enactive approach come from the structure of the MGS: the need for an action is the cause of the meaning generation by and for the system. The action on the environment is for the system to maintain its nature (its identity). The MGS links together the generation of meaningful representations, the nature of the system, and the interactions with the environment. This can be considered as close to enacting a world by meaning generation (Di Paolo and all 2007), and to the enactive concept of sense making (De Jaegher, Di Paolo 2007). We propose that basing the definition of a representation on the notion of meaningful information generated by a system submitted to a constraint can open a way for making the notion of representation compatible with the enactive approach. In the third part of the presentation, we consider some cases of meaningful information and representations for organisms and for robots. Regarding organisms, the MGS can be used in an evolutionary context by looking at the evolution of the systems and of the constraints. Purpose is to modelize the generation of meanings and of representations in order to make available a tool usable for different levels of evolution, as evolution has a place in cognitive sciences (Proust, 2007). Constraints for basic life are survival constraints (individual and species). Group life constraints are also to be considered. Reaching the level of humans in evolution brings in new constraints that cannot be clearly identified as they have to take into account human consciousness which is today a mystery (the “hard problem”). On an evolutionary standpoint, human constraints come in addition to the ones existing for non human organisms. We can make some hypothesis on the nature of human constraints (Maslow pyramid based constraints, anxiety limitation…). For robots, the MGS is initially based on the design of the robot. The meaning generated within a robot is initially derived from the constraints implemented by the designer and from the environment. But some non calculable or non predictable evolutions of the robot can introduce meanings that look proper to the robot. This last point can be linked to the notion of autonomy in robots. In such examples, the dynamic management of meanings thru the MGSs in their environments keeps the link with the enactive approach. We finish the presentation by summarising the points addressed and by proposing several continuations. (shrink)